Xue Han

Xue Han, Ph.D.

Assistant Professor, Biomedical Engineering Department
Joint Professor, Dept. of Pharmacology and Experimental Therapeutics
Member, Photonics Center
Boston University
44 Cummington St., Boston, MA 02215

Email: xuehan@bu.edu

Web: http://www.bu.edu/hanlab

****** Xue leads a neuroengineering lab at Boston University, Biomedical Engineering Department. Her lab is discovering design principles for novel neuromodulation therapies. Please visit her lab's webpage http://www.bu.edu/hanlab for updated inforamtion. ******

Xue is developing radical new genetic, molecular, and optical neurotechnologies and application protocols to treat neurological and psychiatric diseases. Here are some papers Xue wrote:

M. M. McCarthy, C. Moore-Kochlacs, X. Gu, E. S. Boyden, X. Han, and N. Kopell, Striatal origin of the pathologic beta oscillations in Parkinson’s disease, PNAS 108:11620-11625 (2011)

Han, X.*, Chow, B. Y.*, Zhou, H., Klapoetke, N. C., Chuong, A., Rajimehr, R., Yang, A., Baratta, M. V., Winkle, J., Desimone, R., Boyden, E. S. (2011) A high-light sensitivity optical neural silencer: development and application to optogenetic control of non-human primate cortex. Frontiers in Systems Neuroscience. 5:18. doi: 10.3389/fnsys.2011.00018 (2011)

Chow, B. Y.*, Han, X.*, Dobry, A. S., Qian, X., Chuong, A. S., Li, M., Henninger, M. A., Belfort, G. M., Lin, Y., Monahan, P. E., Boyden, E. S. High-performance genetically targetable optical neural silencing by light-driven proton pumps, Nature 463:98-102. (2010) (* equal contributions)

Xue Han, Sherry X. Xian, and Tirin Moore, “Dynamic sensitivity of area V4 neurons during saccade preparation”, PNAS 106(31):13046-51 (2009)

Xue Han, Xiaofeng Qian, Jacob G. Bernstein, Hui-hui Zhou, Giovanni Talei Franzesi, Patrick Stern, Roderick T. Bronson, Ann M. Graybiel, Robert Desimone and Edward S. Boyden, “Millisecond-Timescale Optical Control of Neural Dynamics in the Nonhuman Primate Brain,” Neuron 62(2):191-8 (2009)

Xue Han, Xiaofeng Qian, Patrick Stern, Amy Chuong and Edward S. Boyden, “Informational lesions: optical perturbation of spike timing and neural synchrony via microbial opsin gene fusions”, Front. Mol. Neurosci 2, 12, (2009)

Xue Han and Edward S. Boyden. "Multiple-Color Optical Activation, Silencing, and Desynchronization of Neural Activity, with Single-Spike Temporal Resolution." PLoS ONE, 2(3):e299. (2007)

Xue Han and Meyer B. Jackson. “Structural Transitions in the Synaptic SNARE Complex during Calcium triggered exocytosis.”J Cell Biol. 172(2): 281-93 (2006)

Xue Han and Meyer B. Jackson. “Electrostatic interactions between the syntaxin membrane anchor and neurotransmitter passing through the fusion pore.” Biophys J. 88 (3): L20-2 (2005)

Xue Han, Chih-Tien Wang, Jihong Bai, Edwin R. Chapman and Meyer B. Jackson. “Transmembrane segments of syntaxin line the fusion pore of Ca2+-triggered exocytosis.” Science 304 (5668): 289-92 (2004)